Evidence map›Paper›PMID 41756420›Full record

ArticleResearch square2026

Altered sensory neuron activity in a mouse model of post-burn pain and itch.

Hirotake Ishida, Darya Pavlenko, Kent Sakai, Zeynep Gizem Todurga-Seven, Morini Tammineni, Takashi Hashimoto, Anika Markan, Ernesto Balbin, Maria Boulina, Tasuku Akiyama

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Hirotake IshidaUniversity of Miami Miller School of Medicine.
Darya PavlenkoUniversity of Miami Miller School of Medicine.
Kent SakaiUniversity of Miami Miller School of Medicine.
Zeynep Gizem Todurga-SevenUniversity of Miami Miller School of Medicine.
Morini TammineniUniversity of Miami Miller School of Medicine.
Takashi HashimotoUniversity of Miami Miller School of Medicine.
Anika MarkanUniversity of Miami Miller School of Medicine.
Ernesto BalbinUniversity of Miami Miller School of Medicine.
Maria BoulinaUniversity of Miami Miller School of Medicine.
Tasuku AkiyamaUniversity of Miami Miller School of Medicine.

Funding

Interplay Between Langerhans Cells and Sensory Neurons: Impact on Wound Healing and Nociception Following Burn InjuriesR01GM155523 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Tasuku Akiyama · 2024 to 2026
$990k
Role of Langerhans Cell-Sensory Neuron Interactions in Wound Healing and Nociception After Burn InjuryR56AR080481 · NIAMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI AKIYAMA, TASUKU · 2022 to 2022
$410k
NIAMS NIH HHS R56 AR080481NIGMS NIH HHS R01 GM155523
6 · The paper itself

Abstract

Burn injury induces pain and is frequently accompanied by persistent itch during wound healing. However, the underlying neural mechanisms remain poorly understood. Here, we developed a mouse model of post-burn pain and itch and examined changes in primary sensory neuron activity using

Indexed as

MrgprA3Peripheral sensitizationPopulation codingPruritusTRPV1

Identifiers

PMID41756420
PMCPMC12934996

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.