Evidence map›Paper›PMID 41756404›Full record

ReviewEnvironmental health insights2026

Sustainability in Injectable Drug Delivery Devices: A Systematic Literature Review of Environmental, Economic, and Public Health Impacts.

Eric P Borrelli, Matthias Borms, Monica Telinoiu, Haymen Girgis, Cecile Frolet, Julia D Lucaci

Abstract readReview
In one paragraph

Review in Environmental health insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eric P BorrelliBecton, Dickinson and Company, Franklin Lakes, NJ, USA.
Matthias BormsBecton, Dickinson and Company, Le Pont-de-Claix, France.ORCID https://orcid.org/0009-0008-5019-4217
Monica TelinoiuBecton, Dickinson and Company, Franklin Lakes, NJ, USA.
Haymen GirgisBecton, Dickinson and Company, Le Pont-de-Claix, France.
Cecile FroletBecton, Dickinson and Company, Le Pont-de-Claix, France.
Julia D LucaciBecton, Dickinson and Company, Franklin Lakes, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sustainable injectable drug delivery devices, such as prefilled syringes, multi-chamber syringes, and reusable systems, are gaining attention due to their potential to decrease resource use and waste. Despite these considerations, the integration of sustainability metrics into healthcare systems and pharmaceutical manufacturing is inconsistent, necessitating a systematic review of existing practices and outcomes. Methods: To address this gap, a systematic literature review (SLR) was conducted in June 2024, utilizing the databases of PubMed/MEDLINE and Embase. The studies were examined for sustainability outcomes related to environmental impact, economic efficiency, and public health benefits of injectable drug delivery systems. Cost adjustments were standardized to their respective 2024 currency along with U.S. dollars using price indices for the United States, United Kingdom, Netherlands, and Italy. Results: The literature search returned 2384 unique articles, with 24 studies meeting the inclusion criteria. The reviewed studies highlighted some of the potential benefits of sustainable injectable drug delivery devices. Environmental assessments reported reductions in waste and CO Conclusion: This review suggests that sustainable injectable drug delivery devices can reduce environmental impact, improve economic efficiency, and contribute to public health. By limiting waste, reducing carbon emissions, and supporting safety, these devices can offer measurable contributions for advancing sustainability in healthcare. However, the lack of clear sustainability standards and guidance from health systems and governments remains a key barrier to broader adoption.

Indexed as

drug wastageefficiencyenvironmental impactmulti-chamber syringesprefilled syringesrecyclingreusable devicessustainabilitysustainable drug delivery

Identifiers

PMID41756404
PMCPMC12932899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.