ArticleFrontiers in medicine2026
Association between CD56, CD38 and chronic endometritis and analysis of pregnancy prognosis: a single-center retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The clinical symptoms of chronic endometritis (CE) are atypical, but it is correlated with adverse pregnancy outcomes. The accuracy of its detection needs to be further improved. This article aims to study the association between immunohistochemical CD56, CD38, and CE, and to explore their effect on pregnancy outcomes. Methods: A retrospective analysis was conducted on the clinical data of 844 patients who underwent hysteroscopy check/surgery in the Department of Traditional Chinese Medicine of Zhejiang Provincial People's Hospital from May 1, 2023 to October 31, 2024. The expression levels of CD56 and CD38 and the 12-week continuous pregnancy rate were compared between the CE group and the non-CE group. The optimal cut-off values of CD56 and CD38 were taken based on the ROC curve to explore their diagnosis value for CE and predictive value for pregnancy outcomes. Results: Among the 844 patients, the levels of CD56 and CD38 in the CE group were both higher than those in the non-CE group ( Conclusion: CD56 and CD38 are associated with CE. Various immunohistochemicals can be utilized to improve the accuracy of CE diagnosis, and CD38 is better for evaluating pregnancy outcomes.
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