Evidence map›Paper›PMID 41756389›Full record

ArticleFrontiers in medicine2026

Luteal-phase stimulation does not compromise embryo euploidy or live birth outcomes compared to follicular-phase stimulation.

Boyuan Chen, Meiling Zhang, Min Wang, Yong Wang, Xiaojun Chen, Li Wang, Wen Li, Dandan Wu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Boyuan Chen *The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Meiling Zhang *The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Min WangThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yong WangThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiaojun ChenThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Li WangThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wen LiThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dandan WuThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aneuploidy is a major cause of implantation failure and miscarriage in assisted reproductive technology. This study aimed to evaluate embryo euploidy and live birth rates associated with the luteal-phase stimulation (LPS) protocol in Methods: We conducted a retrospective cohort study at a university-affiliated fertility center, including 667 preimplantation genetic testing for aneuploidy (PGT-A) cycles performed between January 2020 and June 2023. After 1:1 propensity score matching, 106 cycles were analyzed from each group (LPS and FPS). Baseline characteristics, ovarian stimulation parameters, euploidy rate, and subsequent reproductive outcomes were compared. Results: After matching, baseline characteristics were comparable between the groups. The LPS group required a longer duration of gonadotropin stimulation (median 10.5 vs. 9 days, Conclusion: The LPS protocol demonstrated similar embryo euploidy and live birth rates to the FPS protocol, suggesting that LPS does not compromise chromosomal competence or reproductive outcomes. However, the lower oocyte yield in the LPS group could potentially affect cumulative pregnancy and live birth rates. Given its scheduling flexibility, LPS may still represent a clinically feasible and patient-friendly option in assisted reproductive technology (ART).

Indexed as

assisted reproductive technologycontrolled ovarian stimulationeuploidyluteal-phase stimulationpreimplantation genetic testing for aneuploidy (PGT-A)

Identifiers

PMID41756389
PMCPMC12932428

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