Evidence map›Paper›PMID 41756358›Full record

ArticleCurrent research in food science2026

2'-Fucosyllactose and its metabolites propionate/butyrate suppress inflammation through a shared TLR4/p38 MAPK-dependent pathway

Kai Na, Cheng Chao, Tianfei Yu, Liqun Wang, Xiaotong Liu, Li Zhang, Kejue Feng, Junhua Lei, Yu Xiong, Xiaohua Guo

Abstract read
In one paragraph

Article in Current research in food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai NaCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.
Cheng ChaoCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.
Tianfei YuCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.
Liqun WangCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.
Xiaotong LiuCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.
Li ZhangCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.
Kejue FengHubei Province Nutrition Chemicals Biosynthetic Engineering Technology Research Center, Wuhan City, 430074, China.
Junhua LeiHubei Province Nutrition Chemicals Biosynthetic Engineering Technology Research Center, Wuhan City, 430074, China.
Yu XiongHubei Province Nutrition Chemicals Biosynthetic Engineering Technology Research Center, Wuhan City, 430074, China.
Xiaohua GuoCollege of Life Science, South-Central Minzu University, No. 182, Minyuan Road, Hongshan District, Wuhan City, 430074, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

2'-Fucosyllactose (2'-FL), the most abundant human milk oligosaccharide (HMO), exhibits potent anti-inflammatory properties, yet the underlying mechanisms remain incompletely understood. This study employed an integrated approach combining

Indexed as

2′-FLIntestinal inflammationMolecular dockingSCFAsTLR4/p38 MAPK

Identifiers

PMID41756358
PMCPMC12934225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.