ArticleConservation physiology2026
Methods for analysing wildlife DNA methylation data.
Article in Conservation physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The analysis of DNA methylation data for wildlife conservation is gaining momentum as the technology for quantifying the methylome becomes mainstream. The use of epigenetic information extracted from tissue samples can be used for estimating chronological age, individual traits and phenotypic variation. Methylation data present an exciting opportunity to study wildlife populations, with the potential to provide insights into age structure, vital rates and health. However, the statistical methodology for answering the emerging research questions has been developed and mostly applied in the human biomedical setting. We review the key methodologies commonly used in wildlife settings, and methods that have been used only in human studies so far that could improve our understanding of wildlife epigenomic changes. We show how the different methods relate to each other and how they link to research questions, illustrating each approach with data from a case study, a large dataset from wild bottlenose dolphins (
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