Evidence map›Paper›PMID 41756304›Full record

ArticleFrontiers in immunology2026

Characterizing tumor microenvironment heterogeneity in EBV

Siyu Qian, Zeyuan Wang, Yue Zhang, Wanyue Zhao, Honghan Qiao, Xiaoyan Feng, Yukai Duan, Boyuan Su, Shifeng Hao, Zhenzhen Yang and 5 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Siyu Qian *Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zeyuan Wang *Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yue ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wanyue ZhaoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Honghan QiaoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoyan FengDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yukai DuanDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Boyuan SuAcademy of First Clinical, Zhengzhou University, Zhengzhou, China.
Shifeng HaoDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zhenzhen YangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mingzhi ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qingjiang ChenHenan Academy of Innovations in Medical Science, Zhengzhou, China.
Guannan WangDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shenglei LiDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xudong ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Epstein-Barr virus (EBV)-positive nodal T/NK-cell lymphoma (EBV Methods: We applied spatial transcriptomics and multiplex immunofluorescence to representative ENKTL and EBV Results: Spatial transcriptomics revealed fundamental differences between ENKTL and EBV Conclusion: This study delineates the immunologic and molecular architectures of ENKTL and EBV

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanLymphoma, Extranodal NK-T-CellMacrophage Migration-Inhibitory FactorsTumor MicroenvironmentFemaleHumansRetrospective StudiesSpatial TranscriptomicsMacrophage Migration-Inhibitory FactorsEBV - Epstein–Barr virusEBV+ nTNKLENKTLspatial transcriptomicsTME

Identifiers

PMID41756304
PMCPMC12933425

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.