Evidence map›Paper›PMID 41756233›Full record

ReviewFrontiers in pharmacology2026

From dopamine to muscarine: xanomeline-trospium (KarXT) as a novel direction in the psychopharmacotherapy of schizophrenia.

Kacper Żełabowski, Wojciech Pichowicz, Julia Dembowska, Maciej Szwajkowski, Daria Mykhailova, Grzegorz Wurm, Kamil Biedka, Katarzyna Błaszczyk, Patryk Piotrowski

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kacper Żełabowski *Department of Forensic Medicine, Scientific Society for Psychopharmacology, Wrocław Medical University, Wrocław, Poland.
Wojciech Pichowicz *Department of Forensic Medicine, Scientific Society for Psychopharmacology, Wrocław Medical University, Wrocław, Poland.
Julia DembowskaDepartment of Forensic Medicine, Scientific Society for Psychopharmacology, Wrocław Medical University, Wrocław, Poland.
Maciej SzwajkowskiDepartment of Forensic Medicine, Scientific Society for Psychopharmacology, Wrocław Medical University, Wrocław, Poland.
Daria MykhailovaDepartment of Biochemistry and Immunochemistry, Wroclaw Medical University, Wrocław, Poland.
Grzegorz WurmDepartment of Forensic Medicine, Scientific Society for Psychopharmacology, Wrocław Medical University, Wrocław, Poland.
Kamil BiedkaDepartment of Physiology and Pathophysiology, Wrocław Medical University, Wrocław, Poland.
Katarzyna BłaszczykDepartment of Forensic Medicine, Scientific Society for Psychopharmacology, Wrocław Medical University, Wrocław, Poland.
Patryk PiotrowskiDepartment of Psychiatry, Wrocław Medical University, Wrocław, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is a severe chronic mental disease with considerable prevalence and social load. Its treatment relies on both typical and atypical antipsychotics, whose primary mechanism of action involves dopamine D

Indexed as

antipsychotic drugscholinergic modulationKarXTpsychopharmacotherapyschizophreniaxanomeline-trospium

Identifiers

PMID41756233
PMCPMC12932570

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.