ArticleFrontiers in neurology
Pre-procedural vitamin D deficiency and poor prognosis post-thrombectomy in patients with acute anterior circulation large vessel occlusion: a retrospective cohort study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vitamin D deficiency is associated with poor prognosis of stroke. However, its role after mechanical thrombectomy (MT) in acute ischemic stroke (AIS) remains unclear. This study aimed to explore the relationship between pre-procedural vitamin D levels and the clinical prognosis of AIS patients after MT. Methods: A total of 113 AIS patients with successful MT were enrolled in this study and their clinical data were analyzed. Patients were divided into two groups based on their 3-month modified Rankin Scale scores (mRS: 0-2 vs. 3-6). Predictors of adverse prognosis were determined using multivariate logistic regression analysis. In order to evaluate nonlinear associations and mortality risk, restricted cubic spline (RCS) models, receiver operating characteristic (ROC) curve analysis, and Kaplan-Meier survival curve analysis were used. Results: In the patient cohort, compared to the favorable outcome group (mRS 0-2; 31%), patients with poor outcomes (mRS 3-6; 69%) exhibited significantly lower pre-procedural vitamin D levels (14.72 vs. 28.38 ng/mL). Multivariate logistic regression analysis identified severe vitamin D deficiency, delayed recanalization, and elevated high-sensitivity C-reactive protein as independent risk factors. RCS analysis revealed a nonlinear threshold effect of vitamin D on prognosis, with an inflection point at 20 ng/mL. Patients with severe vitamin D deficiency (<10 ng/mL) exhibited markedly higher 180-day mortality compared to those with normal vitamin D levels (≥30 ng/mL) (38.1% vs. 5.0%). Conclusion: Pre-procedural vitamin D deficiency is independently associated with poor functional outcomes and increased mortality after successful MT. Our findings highlight the potential prognostic value of vitamin D assessment in this patient population. Future interventional studies are needed to determine whether correcting vitamin D deficiency could optimize post-thrombectomy management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.