Evidence map›Paper›PMID 41756158›Full record

ArticleJHLT open2026

Lung retransplantation after initial single lung transplantation.

Hailey A Theeuwen, John Croom Sueiro Rodman, Lynette A Lester, Brooks V Udelsman, Graeme M Rosenberg, Sean C Wightman, Anthony W Kim, Scott M Atay, Takashi Harano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hailey A TheeuwenDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
John Croom Sueiro RodmanBiostatistics, Epidemiology, and Research Design, Southern California Clinical and Translational Science Institute, the University of Southern California, Los Angeles, CA.
Lynette A LesterDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Brooks V UdelsmanDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Graeme M RosenbergDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Sean C WightmanDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Anthony W KimDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Scott M AtayDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Takashi HaranoDivision of Thoracic Surgery, Department of Surgery, Keck School of Medicine, the University of Southern California, Los Angeles, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Following single lung transplantation, there are three retransplantation options: contralateral single lung retransplantation (CLSLRT), ipsilateral single lung retransplantation (ILSLRT), and double lung retransplantation (DLRT). The aim of this study is to investigate the effect of recipient lung pathology and retransplant type on survival outcomes. Methods: Patients undergoing lung retransplantation after initial single lung transplantation were identified using the UNOS database, May 2005-December 2022. Patients were grouped by primary diagnosis at initial lung transplantation into obstructive lung disease (OLD), pulmonary vascular disease, cystic fibrosis, or restrictive lung disease (RLD). Results: Of the 418 prior single lung transplant recipients, 38.8% (162/418) underwent initial single lung transplant for OLD, and 58.3% (244/418) for RLD. Among those with OLD, 67.3% (109/162) underwent CLSLRT and 24.1% (39/162) underwent DLRT. OS was similar at 5 years (CLSLRT 47.5% [95%CI 38.7-58.3%]; DLRT 48.0% [95%CI 34.1-67.6%]; Log-rank test, n=148, p=0.77). Among those with RLD, retransplants were as follows: 13.1% (32/244) ILSLRT, 52.9% (129/244) CLSLRT, 34.0% (83/244) DLRT, and the five-year OS was not significantly different between type of retransplantation (ILSLRT 22.1% [95%CI 12.1-40.4%]; CLSLRT 38.8% [95%CI 32.8-45.8%]; DLRT 37.7% [95%CI 29.5-48.2%]; Log-rank test, n=244, p=0.46). In a subgroup analysis of patients with RLD and bronchiolitis obliterans syndrome, 5-year OS was 36.5% (95%CI 22.7-58.9%) with CLSLRT and 48.2% (95%CI 30.4-76.7%) with DLRT (Log-rank test, n=62, p=0.26). Conclusions: Survival outcomes following lung retransplantation after single lung transplant did not differ significantly by retransplant type. These findings suggest that retransplant strategy should be individualized, considering technical feasibility and recipient factors.

Indexed as

Bronchiolitis oblitarans syndromeChronic lung allograft dysfunctionContralateral single lung retransplantationDouble lung retransplantationIpsilateral single lung retransplantationLung retransplantation

Identifiers

PMID41756158
PMCPMC12933290

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.