Evidence map›Paper›PMID 41756135›Full record

ArticleMolecular and clinical oncology2026

Expression and significance analyses of microRNAs in colorectal cancer.

Jing Zhang, Liwei Sun, Changxiu Yan, Honggang Ran, Kaiyong Qu, Zhijian Chen, Argen Bahet, Chenxi Wang, Xin Cai, Guohong Zhuang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jing ZhangDepartment of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Liwei SunOrgan Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Changxiu YanOrgan Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Honggang RanSchool of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Kaiyong QuSchool of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Zhijian ChenSchool of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Argen BahetSchool of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Chenxi WangSchool of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Xin CaiSchool of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Guohong ZhuangOrgan Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.
Zeyang LinDepartment of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs or miRs) serve as potential diagnostic and prognostic markers or therapeutic targets. However, their roles in the pathogenesis of colorectal cancer (CRC) is not fully understood. The aim of the present study was to investigate the expression levels and functions of miR-205, miR-376c, and miR-539 in CRC development and prognosis. Multiple GEO databases were used to explore miRNA expression levels and associations in CRC cancer and adjacent/normal tissues. In addition, the associations between the expression of the miRNAs and the clinicopathological features of CRC were analyzed. The clinical data and specimens of 25 patients with CRC were collected, detected and analyzed. Combining bioinformatics analysis and databases, the relationship between the three miRNAs and CRC progression and prognosis was explored. In the GSE41655 dataset, miR-376c, miR-539, and miR-205 were all downregulated in tumor tissues, with miRNA-376c exhibiting the most pronounced downregulation. MiR-376c was closely associated with CRC liver metastasis, especially in the synchronous metastasis condition. Additionally, in the miRDB database, an analysis of the overlapping predicted target genes for miR-205, miR-376c, and miR-539 revealed that these three miRNAs share 53 common predicted target genes. Not only did miR-539 and miR-205 significantly differ according to tumor stage and lymph node metastasis, but also their upregulation was significant in tumor advanced stage and lymph node metastasis according to logistic regression in collected cancer tissues. Furthermore, miR-205 was significantly upregulated in tumor differentiation according to logistic regression. In conclusion, miR-205, miR-376c, and miR-539 were revealed to be involved in the development and prognosis of CRC and may be potential targets for CRC therapy.

Indexed as

colorectal cancermiR-205miR-376cmiR-539

Identifiers

PMID41756135
PMCPMC12933723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.