ArticlePNAS nexus2026
Peptide ligase-mediated display: A cell-free platform for tunable selection of affinity peptides.
Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Herein, we report a bead-surface protein display method based on a peptidyl transferase reaction, termed peptide ligase-mediated display (PL display). This technique enables the covalent linkage of genotypic DNA and phenotypic protein variants on beads via a minimal nine-amino acid linker in a fully cell-free system. Using this method, hemagglutinin (HA)-tag sequences introduced at a 0.01% frequency were completely isolated in a single round of selection via fluorescence-activated cell sorting (FACS) against an anti-HA-tag antibody. Furthermore, consensus sequences that bind to the anti-HA-tag antibody were enriched from a random peptide library with a sequence diversity of 1.7 × 10
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