Evidence map›Paper›PMID 41756034›Full record

ArticleEuropean journal of anaesthesiology and intensive care2026

Unmasking of SGLT2 inhibitor associated ketoacidosis after initiation of mechanical ventilation with consecutive cardiopulmonary resuscitation and extracorporeal life support: A case report.

Johannes Nienhaus, René M'Pembele, Detlef Kindgen-Milles, Hannan Dalyanoglu, Sebastian Roth

Abstract readCase Reports
In one paragraph

Article in European journal of anaesthesiology and intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johannes NienhausFrom the Department of Anesthesiology, University Hospital Duesseldorf, Germany (JN, RMP, DK-M, SR), the Department of Cardiac Surgery, University Hospital Duesseldorf, Germany (HD).
René M'PembeleFrom the Department of Anesthesiology, University Hospital Duesseldorf, Germany (JN, RMP, DK-M, SR), the Department of Cardiac Surgery, University Hospital Duesseldorf, Germany (HD).
Detlef Kindgen-MillesFrom the Department of Anesthesiology, University Hospital Duesseldorf, Germany (JN, RMP, DK-M, SR), the Department of Cardiac Surgery, University Hospital Duesseldorf, Germany (HD).
Hannan DalyanogluFrom the Department of Anesthesiology, University Hospital Duesseldorf, Germany (JN, RMP, DK-M, SR), the Department of Cardiac Surgery, University Hospital Duesseldorf, Germany (HD).
Sebastian RothFrom the Department of Anesthesiology, University Hospital Duesseldorf, Germany (JN, RMP, DK-M, SR), the Department of Cardiac Surgery, University Hospital Duesseldorf, Germany (HD).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are widely used for the treatment of type 2 diabetes, heart failure and chronic kidney disease due to their proven cardiovascular and renal benefits. However, they carry the risk of SGLT2i associated ketoacidosis, a rare but potentially life-threatening complication that can present without marked hyperglycaemia, often leading to delayed recognition. Although guidelines currently recommend discontinuing SGLT2i perioperatively and during acute illness, recent retrospective studies have questioned this approach, suggesting that perioperative continuation may not increase the incidence of SGLT2i associated ketoacidosis and could improve outcomes. While this trend is acknowledged, the present case highlights the dangers of continuing SGLT2i therapy in the intensive care setting with a special focus on the initiation of mechanical ventilation and underscores the need for an individualised management.

Identifiers

PMID41756034
PMCPMC12935407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.