ArticleNeuroscience applied2026
Response to immune-based augmentation treatment for depression: a potential role of immunosenescence.
Article in Neuroscience applied, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunological processes are increasingly in focus as factors contributing to major depressive disorder (MDD). Especially subtypes such as immunometabolic depression phenotypes have been linked to low-grade inflammation. Augmentation with immune-based therapies, e.g., celecoxib, is being tested for its efficacy in treating depression. Many physiological processes during life are also linked to immunological changes, particularly aging. As results from current trials with celecoxib augmentation remain inconclusive, we tested the hypothesis that age affects treatment efficacy. In total, 113 individuals with a diagnosis of major depressive disorder (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.