ArticleJGH open : an open access journal of gastroenterology and hepatology2026
Dosing and Route of Steroid Induction Therapy in Non-Severe Autoimmune Hepatitis Do Not Affect Time to Biochemical Response.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Optimal steroid induction therapy in autoimmune hepatitis (AIH) is unclear. We aimed to investigate the relationship between steroid dosing, route of administration, and time to biochemical response to help standardize AIH practice patterns and reduce excess steroid exposure. Methods: We conducted a retrospective cohort study of adult patients with non-severe AIH receiving induction steroid therapy. Patients were stratified into three treatment groups: (1) low-dose oral steroids ( Results: Rates of biochemical response were similar between the low- and high-dose oral steroid groups at 6 months (72% vs. 78%, Conclusions: Lower dose prednisone may be an effective initial induction regimen in outpatients with AIH. Similarly, oral steroids may be non-inferior to IV steroids. Together, these results favor a more conservative approach for non-severe AIH induction therapy.
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