Evidence map›Paper›PMID 41755863›Full record

ArticleJACS Au2026

Diterpene Molecular Glue Stabilizes Protein-Protein Interactions of a Disordered Phosphoprotein that Controls Translational Repression.

Nanami Ogino, Ryoma Masuda, Shota Igaue, Mei Arita, Ami Matsumura, Yumi Ieda, Makoto Muroi, Ken Matsumoto, Reiko Nakagawa, Yusuke Higuchi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nanami OginoAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.
Ryoma MasudaAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.
Shota IgaueAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.
Mei AritaAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.
Ami MatsumuraAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.
Yumi IedaAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.
Makoto MuroiRIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.ORCID https://orcid.org/0000-0002-4323-9527
Ken MatsumotoRIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.ORCID https://orcid.org/0000-0002-7864-3394
Reiko NakagawaLaboratory for Cell-Free Protein Synthesis, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Hyogo, Japan.ORCID https://orcid.org/0000-0002-6178-2945
Yusuke HiguchiInstitute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Osaka 567-0047, Ibaraki, Japan.ORCID https://orcid.org/0000-0002-5982-9660
Hiroyuki OsadaRIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.ORCID https://orcid.org/0000-0002-3606-4925
Minoru YoshidaRIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Isao KiiAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.ORCID https://orcid.org/0000-0002-6153-6250
Junko OhkandaAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, Japan.ORCID https://orcid.org/0000-0001-9663-5104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical stabilization of protein-protein interactions involving intrinsically disordered phosphoproteins is an emerging yet challenging problem. Synthetic agents capable of achieving this goal are desirable for advancing understanding of the biological roles of these transient interactions and for developing new therapeutics. 12-Deoxyfusicoccin (

Indexed as

14-3-3AMPKGIGYF2intrinsically disordered phosphoproteinsmolecular glueprotein−protein interactionsstress responsestranslational repression

Identifiers

PMID41755863
PMCPMC12933339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.