Evidence map›Paper›PMID 41755814›Full record

ArticleJACS Au2026

Aqueous-Phase Polycondensation of Hydroxy Fatty Acids via a Whole-Cell CoA Activation-Acyltransferase Cascade.

Shuming Jin, Dong Lu, Qiuyang Wu, Yulu Zhang, Ni Jiang, Junfeng Liu, Fang Wang, Jan Baeyens, Li Deng, Kaili Nie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shuming JinCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Dong LuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Qiuyang WuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Yulu ZhangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Ni JiangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID https://orcid.org/0000-0003-4706-9884
Junfeng LiuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID https://orcid.org/0000-0002-6737-9794
Fang WangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Jan BaeyensDepartment of Chemical Engineering, KU Leuven, 3001 Leuven, Belgium.
Li DengCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID https://orcid.org/0000-0001-8792-529X
Kaili NieCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID https://orcid.org/0000-0002-0613-9850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyester formation by polycondensation in water is limited by an esterification-hydrolysis equilibrium that strongly favors hydrolysis under mild conditions. Although aqueous-phase esterification has been demonstrated with chemical catalysts and isolated enzymes, these systems typically target small-molecule esters or rely on preactivated donors. The polyhydroxyalkanoate (PHA) pathway is the only known native metabolic route for polyester biosynthesis, but it is essentially limited to the polymerization of 3-hydroxybutyrate and related short-chain hydroxyalkanoate monomers. Consequently, realizing efficient aqueous-phase polycondensation to high-molar-mass polyesters remains a major challenge. Here, an intracellular CoA activation/acyltransferase cascade (ACOS5

Indexed as

aqueous-phase polycondensationCoA activation−transfer cascadepolyestertransfer cascadewhole-cell biocatalysisω-hydroxy fatty acid

Identifiers

PMID41755814
PMCPMC12933353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.