Evidence map›Paper›PMID 41755744›Full record

ArticleJournal of medicinal chemistry2026

Selectivity Modulation of Small Cationic Membrane-Active Cyclic Peptides with Broad-Spectrum Activity against Bacteria and Fungi.

Sandeep Lohan, Rakesh Kumar Tiwari, Innokentiy Maslennikov, Kaustav Das Gupta, Shakti Singh, Keykavous Parang

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sandeep LohanCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Rd, Irvine, California 92618, United States.
Rakesh Kumar TiwariCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Rd, Irvine, California 92618, United States.
Innokentiy MaslennikovStructural Biology Research Center, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Rd., Irvine, California 92618, United States.ORCID 0000-0003-4292-5821
Kaustav Das GuptaDivision of Infectious Disease, Los Angeles Medical Center, The Lundquist Institute for Biomedical Innovation at Harbor-University of California, 1124 West Carson Street, Torrance, California 90502, United States.
Shakti SinghDivision of Infectious Disease, Los Angeles Medical Center, The Lundquist Institute for Biomedical Innovation at Harbor-University of California, 1124 West Carson Street, Torrance, California 90502, United States.
Keykavous ParangCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Rd, Irvine, California 92618, United States.ORCID 0000-0001-8600-0893

Funding

Role of multi-drug resistant Candida auris Hyr1 / Iff-like proteins in virulence and their potential as vaccine targetsK01AI180591 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Shakti Singh · 2024 to 2026
$405k
NIAID NIH HHS K01 AI180591
6 · The paper itself

Abstract

To investigate how ring size and backbone flexibility influence antimicrobial potency and cytotoxicity, we synthesized a series of macrocyclic peptides of lead peptide

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBacteriaFungiPeptides, CyclicBiofilmsGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsPeptides, Cyclic

Identifiers

PMID41755744
PMCPMC12990034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.