ArticleLasers in surgery and medicine2026
Targeting the Dynamic Susceptibility Window: Time-Sensitive Photodynamic Synergy With Antibiotics Against Streptococcus spp.
Article in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Antimicrobial Strategies in the Era of Resistance: It Is Too Early to Give Up Antibiotic Therapy.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveEvaluated the antimicrobial efficacy of curcumin-mediated photodynamic inactivation (PDI) against both sensitive and resistant strains of Streptococcus pneumoniae and Streptococcus pyogenes, as well as its potential to enhance antibiotic effects (amoxicillin, ceftriaxone, erythromycin). METHODOLOGY: The minimum inhibitory concentrations of antibiotics A, B, and C were evaluated in S. pneumoniae and S. pyogenes strains using serial microdilution. Additionally, the photodynamic action of curcumin as a photosensitizer was examined in multiwell plates, which were then irradiated with a 450-nm LED. The effect of the combination over time was determined by colony-forming units per milliliter, using the determined subinhibitory parameters of antibiotics and PDI.
resultsPDI alone significantly reduced bacterial viability, achieving over 3-log reductions at optimal conditions (2.5 µM curcumin, 6.4 J/cm
conclusionThe study highlights that optimal timing of PDI application is key to maximizing its synergistic effects with antibiotics, revealing that PDI is most effective when applied during specific stages of bacterial response to antibiotic stress, potentially redefining adjuvant treatment strategies.
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Registered trials
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