Evidence map›Paper›PMID 41755250›Full record

ArticleSensors (Basel, Switzerland)2026

Edge AI-Based Gait-Phase Detection for Closed-Loop Neuromodulation in SCI Mice.

Ahnsei Shon, Justin T Vernam, Xiaolong Du, Wei Wu

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahnsei ShonDepartment of Neurological Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0000-0001-9474-0744
Justin T VernamDepartment of Neurological Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Xiaolong DuKentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY 40202, USA.
Wei WuDepartment of Neurological Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA.ORCID 0009-0001-4056-8923

Funding

Reprogramming reactive glial cells into functional new neurons after SCIR01NS111776 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI WU, WEI, ZHANG, CHUN-LI · 2020 to 2024
$2.4M
Converting the glial scar to neurons repairs the injured neural circuits for functional recovery following spinal cord injuryR01NS131489 · NINDS · UNIVERSITY OF LOUISVILLE · PI Wei Wu · 2024 to 2026
$1.0M
Indiana State Department of Health ISDH, Grant# 58180NIH HHS 1R01NS103481NIH HHS R01NS111776NIH HHS R01NS131489
6 · The paper itself

Abstract

Real-time detection of gait phase is a critical challenge for closed-loop neuromodulation systems aimed at restoring locomotion after spinal cord injury (SCI). However, many existing gait analysis approaches rely on offline processing or computationally intensive models that are unsuitable for low-latency, embedded deployment. In this study, we present a hybrid AI-based sensing architecture that enables real-time kinematic extraction and on-device gait-phase classification for closed-loop neuromodulation in SCI mice. A vision AI module performs marker-assisted, high-speed pose estimation to extract hindlimb joint angles during treadmill locomotion, while a lightweight edge AI model deployed on a microcontroller classifies gait phase and generates real-time phase-dependent stimulation triggers for closed-loop neuromodulation. The integrated system generalized to unseen SCI gait patterns without injury-specific retraining and enabled precise phase-locked biphasic stimulation in a bench-top closed-loop evaluation. This work demonstrates a low-latency, attachment-free sensing and control framework for gait-responsive neuromodulation, supporting future translation to wearable or implantable closed-loop neurorehabilitation systems.

Indexed as

Artificial IntelligenceGaitSpinal Cord InjuriesAnimalsBiomechanical PhenomenaIntelligent SystemsLocomotionMiceclosed-loop neuromodulationedge AIgait analysismachine learningreal-time systemspinal cord injurytreadmill locomotionvision AI

Identifiers

PMID41755250
PMCPMC12944277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.