Evidence map›Paper›PMID 41754970›Full record

ArticlePharmaceutics2026

Unconventional Lysine-Type Lipid Assemblies Enable Efficient Antisense Oligonucleotide Delivery with Distinct Structural Features.

Jieyan He, Whitney Shatz-Binder, Alexandra Robles, Nanzhi Zang, Wei Jia, Sakura Sahai, Matthew C Johnson, Jing Li, Chun-Wan Yen, Shinji Takeoka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jieyan HeBiochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0002-2206-3569
Whitney Shatz-BinderPharmaceutical Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0003-2996-501X
Alexandra RoblesPharmaceutical Development, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0001-7229-0017
Nanzhi ZangSynthetic Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.ORCID 0000-0001-6438-7302
Wei JiaSynthetic Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sakura SahaiDepartment of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan.
Matthew C JohnsonDepartment of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Jing LiBiochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
Chun-Wan YenSynthetic Molecule Pharmaceutical Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Shinji TakeokaAdvanced Research Institute of Science and Engineering, Waseda University, Tokyo 169-8555, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ASOcationic lipidslipoplexLNPnon-viral delivery systemstructure

Identifiers

PMID41754970
PMCPMC12944301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.