Evidence map›Paper›PMID 41754928›Full record

ReviewPharmaceutics2026

Corneal Extracellular Vesicles: Small Packages with a Big Impact.

Brenna S Hefley, Pawan Shrestha, Tina B McKay, Peter Nsiah, Yasamin Moradi, Sarah E Nicholas, Dimitrios Karamichos

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brenna S HefleyNorth Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.ORCID 0000-0002-8953-5102
Pawan ShresthaNorth Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.ORCID 0009-0004-9081-3829
Tina B McKayMass General Brigham Department of Anesthesiology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0003-0130-9272
Peter NsiahNorth Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.ORCID 0009-0000-0467-5492
Yasamin MoradiNorth Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.ORCID 0009-0004-8146-089X
Sarah E NicholasNorth Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.ORCID 0000-0002-1187-4964
Dimitrios KaramichosNorth Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.ORCID 0000-0002-8761-3824

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are small membrane-bound particles that play a vital role in intercellular communication by facilitating the transfer of molecular cargo. In this review, we provide an overview of EV biology in corneal diseases, along with current approaches to therapeutic uses of EVs. Since EVs generally retain surface markers indicative of their cell of origin, they possess a degree of tissue specificity, which benefits drug delivery systems and highlights their potential as biomarkers to study disease processes. Further advances in technology and methodology will accelerate our understanding of EVs and help guide the field towards improved diagnostic techniques and therapeutic targets. We summarize EVs and their potential impact in medicine with a discussion of the limitations that remain in current approaches, as well as areas to focus on for future growth.

Indexed as

biological fluidcharacterizationexosomeextracellular vesiclestherapeutics

Identifiers

PMID41754928
PMCPMC12944481

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.