ArticlePharmaceuticals (Basel, Switzerland)2026
Novel Active Homo-Aza (Lactam) Steroidal Antimetabolites for the Treatment of Human Pancreatic and Colorectal Cancer.
Konstantinos E Alifieris, Panagiotis Dalezis, Sofia Sagredou, Ioanna A Anastasiou, Maria Deligiorgi, Christos Siokatas, Nikolaos Spanakis, Konstantinos Almpanakis, Maria Voura, Kyriakos Orfanakos and 3 more
Abstract read
In one paragraphArticle in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Konstantinos E AlifierisLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.ORCID 0000-0002-4347-413X Panagiotis DalezisLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.ORCID 0000-0001-7680-7685 Sofia SagredouLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.ORCID 0000-0001-9281-7947 Ioanna A AnastasiouLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
Maria DeligiorgiLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
Christos SiokatasLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Science, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.ORCID 0000-0003-4102-9638 Nikolaos SpanakisDepartment of Microbiology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Goudi, 15772 Athens, Greece.
Konstantinos AlmpanakisLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Science, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Maria VouraLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Science, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
Kyriakos OrfanakosLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.ORCID 0009-0001-5124-6727 Mihalis PanayiotidisDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine, Mississippi State University, Starkville, MS 39762, USA.ORCID 0000-0002-1450-3552 Vasiliki SarliLaboratory of Organic Chemistry, Department of Chemistry, Faculty of Science, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.ORCID 0000-0002-6128-8277 Dimitrios T TrafalisLaboratory of Pharmacology, Faculty of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.ORCID 0000-0003-4066-9780 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
antimetabolitesantineoplastic/pharmacologyapoptosis/drug effectscolorectal neoplasms/drug therapydihydrofolate reductase inhibitors/pharmacologyhomo-aza lactam steroidal conjugatesmolecular docking simulationpancreatic neoplasms/drug therapysteroids/pharmacologystructure–activity relationshipthymidylate synthase inhibitors/pharmacology
Identifiers
PMID41754871
PMCPMC12944281
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