Evidence map›Paper›PMID 41754808›Full record

ArticlePharmaceuticals (Basel, Switzerland)2026

Drivers of Methotrexate Polyglutamate Concentration in Erythrocytes: Insights from Immune-Mediated Inflammatory Diseases and Pediatric Acute Lymphoblastic Leukemia.

Janani Sundaresan, Wout J Hamelink, Renske C F Hebing, Maartje van de Meeberg, Montse Janssen Bonás, Inge M van der Sluis, Pascal H P de Jong, Martijn Heymans, Robert de Jonge, Maurits C F J de Rotte and 1 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Janani SundaresanLaboratory of Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.ORCID 0009-0009-7905-0214
Wout J HamelinkLaboratory of Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.
Renske C F HebingDepartment of Pharmacy, Sint Maartenskliniek, 6574 NA Nijmegen, The Netherlands.ORCID 0000-0002-6725-6719
Maartje van de MeebergDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, 1105 AZ Amsterdam, The Netherlands.
Montse Janssen BonásILD Center of Excellence (Member of the European Reference Network-Lung), St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.
Inge M van der SluisPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0002-5822-7668
Pascal H P de JongDepartment of Rheumatology, Erasmus MC, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-6628-6222
Martijn HeymansDepartment of Epidemiology and Data Science, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
Robert de JongeLaboratory of Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-3454-0094
Maurits C F J de RotteLaboratory of Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0002-9213-107X
Maja Bulatović-ĆalasanLaboratory of Specialized Diagnostics & Research, Department of Laboratory Medicine, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

immune-mediated inflammatory diseasesmethotrexate polyglutamatemultivariate linear regression modellingpediatric acute lymphoblastic leukemiapharmacokinetics and drug metabolism

Identifiers

PMID41754808
PMCPMC12943293

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.