Evidence map›Paper›PMID 41754567›Full record

ArticleViruses2026

CryoVirusDB: An Annotated Dataset for AI-Based Virus Particle Identification in Cryo-EM Micrographs.

Rajan Gyawali, Ashwin Dhakal, Liguo Wang, Jianlin Cheng

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Rajan GyawaliDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-7052-4964
Ashwin DhakalDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0002-4047-9947
Liguo WangLaboratory for BioMolecular Structure (LBMS), Brookhaven National Laboratory, Upton, NY 11973, USA.
Jianlin ChengDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0003-0305-2853

Funding

Deep learning methods for automated and accurate reconstruction of protein structures from cryo-EM image dataR01GM146340 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHENG, JIANLIN · 2022 to 2025
$1.4M
National Institute of Health R01GM146340NIGMS NIH HHS R01 GM146340
6 · The paper itself

Abstract

With the advancements in instrumentation, image processing algorithms, and computational capabilities, single-particle cryo-electron microscopy (cryo-EM) has achieved atomic resolution in determining the 3D structures of viruses. The virus structures play a crucial role in studying their biological function and advancing the development of antiviral vaccines and treatments. Despite the effectiveness of artificial intelligence (AI) in general image processing, its development for identifying and extracting virus particles from cryo-EM micrographs has been hindered by the lack of manually labeled high-quality datasets. To fill the gap, we introduce CryoVirusDB, a labeled dataset containing the coordinates of expert-picked virus particles in cryo-EM micrographs. CryoVirusDB comprises 9941 micrographs from nine datasets representing seven distinct non-enveloped viruses exhibiting icosahedral or pseudo-icosahedral symmetry, along with coordinates of 339,398 labeled virus particles. It can be used to train and test AI and machine learning (e.g., deep learning) methods to accurately identify virus particles in cryo-EM micrographs for building atomic 3D structural models for viruses.

Indexed as

Artificial IntelligenceCryoelectron MicroscopyImage Processing, Computer-AssistedVirionVirusesAlgorithmsImaging, Three-DimensionalModels, MolecularAI-based virus particle pickingcryo-electron microscopylabeled datasetstructural biologyviral structure

Identifiers

PMID41754567
PMCPMC12945220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.