Evidence map›Paper›PMID 41754544›Full record

ArticleViruses2026

Single-Cell Sequencing Reveals the Immune Characteristics of Secondary Liver Injury Induced Indirectly by CHIKV Infection in Rhesus Macaques.

Hao Yang, Yun Yang, Cong Tang, Yanan Zhou, Wenhai Yu, Qing Huang, Haixuan Wang, Daoju Wu, Wenqi Quan, Junbin Wang and 1 more

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hao YangInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Yun YangInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Cong TangInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Yanan ZhouInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Wenhai YuInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Qing HuangInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.ORCID 0000-0002-6390-9604
Haixuan WangInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Daoju WuInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Wenqi QuanInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.ORCID 0009-0007-9995-5147
Junbin WangInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.
Shuaiyao LuInstitute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College (IMBCAMS&PUMC), 935 Jiaoling Road, Kunming 650118, China.ORCID 0000-0003-1675-9735

Funding

CAMS Innovation Fund for Medical Sciences; Major project of basic research in Yunnan Province ; High-Level Medical Talent Training Program of Yunnan Province . (2021-I2M-1-038, 2023-I2M-2-001); 3-I2M-2-001);(202401BC070008);(L-2024018)
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is now prevalent in multiple regions worldwide, posing a serious threat to human health. In this study, we have successfully established a rhesus macaque model of Chikungunya virus infection. Notably, while no viral load was detected in liver tissue on day 7 post-infection, significant pathological damage was observed. Single-cell RNA sequencing of liver tissue revealed a reduction in B cells following infection. Among T cells, CD8

Indexed as

Chikungunya FeverChikungunya virusLiverLiver DiseasesAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalMacaca mulattaMacrophagesNatural Killer T-CellsSingle-Cell AnalysisViral Loadchikungunya virus infectionimmune cell activationliver injuryrhesus macaquesingle-cell sequencing

Identifiers

PMID41754544
PMCPMC12945046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.