Evidence map›Paper›PMID 41754540›Full record

ReviewViruses2026

Bridging the Structural Gap: A Methodological Review of Cryo-Electron Microscopy for Underrepresented Viruses.

Yoon Ho Park, Hyun Suk Jung, Sungjin Moon, Chihong Song

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoon Ho ParkDepartment of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.ORCID 0009-0005-8548-380X
Hyun Suk JungDepartment of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.ORCID 0000-0002-2431-1327
Sungjin MoonDepartment of Biological Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
Chihong SongDepartment of Convergence Medicine, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.

Funding

Chihong Song RS-2024-00440289Hyun Suk Jung RS-2025-25436300Sungjin Moon RS-2023-NR07640822182102130003Yoon Ho Park RS-2024-00410337
6 · The paper itself

Abstract

Cryo-electron microscopy (cryo-EM) has revolutionized structural virology, enabling routine structure determination at 2-4 Å resolution, with exceptional cases reaching 1.56 Å. The structural diversity of viruses across vertebrate, plant, and insect hosts provides fundamental insights into infection mechanisms, host-pathogen coevolution, and therapeutic target identification. However, analysis of Electron Microscopy Data Bank entries reveals notable disparities in structural coverage: among 11,717 eukaryotic virus structures (excluding bacteriophages), vertebrate viruses constitute 97.6% (

Indexed as

Cryoelectron MicroscopyVirusesAnimalsInsect VirusesPlant VirusesCryo-EMgiant virusesinsect virusesplant virusesvertebrate viruses

Identifiers

PMID41754540
PMCPMC12945189

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.