Evidence map›Paper›PMID 41754534›Full record

ArticleViruses2026

Characterization of the Genomics and Antigenicity of a Naturally Attenuated Gammacoronavirus Infectious Bronchitis Virus Strain in the Genotype GVI-1 Lineage.

Ting Xiong, Shuting Wu, Yanfen Lyu, Hongmei Li, Mengyao Jing, Zekun Yang, Fei Xu, Shuaibo Shi, Haixia Feng, Dingxiang Liu and 1 more

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Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ting XiongCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.ORCID 0009-0008-0638-4371
Shuting WuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.
Yanfen LyuSchool of Mathematics and Physics, Hebei University of Engineering, Handan 056038, China.
Hongmei LiZhaoqing Branch of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
Mengyao JingZhaoqing Branch of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
Zekun YangZhaoqing Branch of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
Fei XuZhaoqing Branch of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
Shuaibo ShiSchool of Mathematics and Physics, Hebei University of Engineering, Handan 056038, China.
Haixia FengZhaoqing Branch of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.
Dingxiang LiuZhaoqing Branch of Guangdong Laboratory of Lingnan Modern Agricultural Science and Technology, Zhaoqing 526238, China.ORCID 0000-0001-6039-2948
Ruiai ChenCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510640, China.

Funding

Science and technology plan projects funded by self-raised funds of Guangdong Provincial Laboratory XJGDL2022002Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology XJ2025KJ008
6 · The paper itself

Abstract

Infectious bronchitis virus (IBV) causes a highly contagious disease in chickens. The prevalence of GVI-1 is increasing; however, the genomic characteristics and antigenic properties of this genotype strain remain insufficiently characterized. In this study, the genome characteristics and antigenic properties of a naturally attenuated CK/CH/SC/YC_GVI-1-DK/LMB20210104 (abbreviated as YC_GVI-1) strain were systematically analyzed. YC_GVI-1 occupies a distinct phylogenetic lineage and shares a similarity of 98.2%, the highest nucleotide sequence homology, with the reference strain CK/CH/FJ/202005 (accession number: MW791835.1). This strain was likely originated through a genetic recombination event between two major parental strains, CK/CH/FJ/202005 and CK/CH/GX/HX (accession number: PP817796.1). However, its S protein harbors ten unique amino acid substitutions, compared to the same protein in the other two virulent strains in the same genotype. AlphaFold3-based structural prediction reveals that one of these substitutions, methionine 485 to valine substitution, may induce a conformational change in the adjacent phenylalanine residue at position 431, resulting in a shift in the local secondary structure from β-sheet to random coil. Characterization of its antigenicity showed that this strain induces a strong humoral immune response, with neutralizing antibody titers of 2

Indexed as

Antigens, ViralCoronavirus InfectionsGenome, ViralInfectious bronchitis virusAnimalsAntibodies, NeutralizingAntibodies, ViralChickensGenomicsGenotypePhylogenyPoultry DiseasesSpike Glycoprotein, CoronavirusVaccines, AttenuatedViral VaccinesAntibodies, NeutralizingAntibodies, ViralAntigens, ViralSpike Glycoprotein, CoronavirusVaccines, AttenuatedViral Vaccinesantigenic analysisgenome characteristicsIBV

Identifiers

PMID41754534
PMCPMC12945201

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.