Evidence map›Paper›PMID 41754520›Full record

ArticleViruses2026

Impact of Selenium and Vitamin E Deficiency on Zika Virus Pathogenesis and Immune Response in Mice.

Olukunle O Oluwasemowo, Monica E Graham, James B Thissen, Aram Avila-Herrera, Jeffrey A Kimbrel, Deepa K Murugesh, Dina R Weilhammer, Tanya Tanner, Nicole M Collette, Monica K Borucki

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olukunle O OluwasemowoBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.ORCID 0000-0003-0647-498X
Monica E GrahamBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.
James B ThissenBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.
Aram Avila-HerreraGlobal Security Computing Applications Division, Computing Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.
Jeffrey A KimbrelBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.ORCID 0000-0001-7213-9392
Deepa K MurugeshBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.
Dina R WeilhammerBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.ORCID 0000-0002-7618-4702
Tanya TannerBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.ORCID 0000-0001-6390-9543
Nicole M ColletteBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.ORCID 0000-0002-9068-8712
Monica K BoruckiBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550, USA.ORCID 0000-0003-2924-2313

Funding

U.S. Department of Energy LDRD 23-ERD-012
6 · The paper itself

Abstract

Micronutrient status is recognized to influence host susceptibility to viral infections, yet its impact on Zika virus (ZIKV) pathogenesis remains incompletely understood. We investigated the effects of dietary selenium and combined selenium plus vitamin E deficiency on ZIKV infection outcomes in a type I interferon α/β receptor knockout (Ifnar1

Indexed as

SeleniumVitamin E DeficiencyZika VirusZika Virus InfectionAnimalsAntibodies, NeutralizingAntibodies, ViralCytokinesDisease Models, AnimalFemaleImmunity, CellularMiceMice, KnockoutViral LoadAntibodies, NeutralizingAntibodies, ViralCytokinesSeleniumcytokinemutationneuroinvasionnutritionquasispeciesseleniumvitamin EZika virus

Identifiers

PMID41754520
PMCPMC12945010

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.