Evidence map›Paper›PMID 41754516›Full record

ReviewViruses2026

Antiviral Inflammasomes and How to Find Them.

Jennifer Deborah Wuerth, Florian Ingo Schmidt

Abstract readReview
In one paragraph

Review in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer Deborah WuerthInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-3391-9633
Florian Ingo SchmidtInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9979-9769

Funding

Deutsche Forschungsgemeinschaft SPP1923-429513120
6 · The paper itself

Abstract

Inflammasomes are signaling complexes of the innate immune system that are assembled in distinct sentinel cell types to coordinate inflammation. As demonstrated by the emergence of viral antagonists and evasion mechanisms, inflammasomes are critical to contain viral infections. As virions are entirely composed of host cell-derived molecules, infection is either recognized by molecules or modifications exposed in unusual compartments, or by activities and host cell damage indicative of virus replication. Rather than enumerating all viruses that activate inflammasomes, this review classifies common pathways or signatures that activate antiviral inflammasomes. We define a set of minimal criteria that we think is critical to prove virus-triggered inflammasome assembly. We further discuss the consequences of virus-induced inflammasome assembly and define relevant open questions in the field.

Indexed as

InflammasomesVirus DiseasesVirusesAnimalsHost-Pathogen InteractionsHumansImmunity, InnateInflammationInnate Immunity RecognitionSignal TransductionVirus ReplicationInflammasomesASC speckinflammasomeinflammationinnate immune systemretrovirusvirus

Identifiers

PMID41754516
PMCPMC12945228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.