Evidence map›Paper›PMID 41754504›Full record

ArticleViruses2026

A Retrospective Cohort Study on HHV-8 Viral Load and Prognosis in HIV-Associated Kaposi Sarcoma Among People Living with HIV in Japan.

K Ishikawa, T Muramatsu, S Kaneko, Y Harada, R Miyashita, Y Kamikubo, T Yamaguchi, A Ichiki, Y Chikasawa, M Bingo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

K IshikawaDepartment of Microbiology, Tokyo Medical University, Tokyo 160-8402, Japan.ORCID 0000-0003-2502-6955
T MuramatsuDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
S KanekoDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
Y HaradaDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
R MiyashitaDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
Y KamikuboDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
T YamaguchiDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
A IchikiDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
Y ChikasawaDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.ORCID 0000-0001-6867-3613
M BingoDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
R SekiyaDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.ORCID 0000-0003-1292-1707
M YotsumotoDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.ORCID 0000-0001-5771-7190
T HagiwaraDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
K AmanoDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.
E KinaiDepartment of Laboratory Medicine, Tokyo Medical University Hospital, Tokyo 160-0023, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe characteristics and prognosis of HIV-associated Kaposi sarcoma (KS) among people living with HIV (PLWH), and their association with HHV-8 viral load are not well understood in Japan.

methodsWe conducted a retrospective study of PLWH diagnosed with KS at Tokyo Medical University from 2000 to 2023.

resultsSeventy cases of KS were identified; HHV-8 viral load data were available for twenty-three of these cases. The median age was 43 years (interquartile range [IQR], 11 years). The median HIV viral load at diagnosis was 150,000 copies/mL (IQR, 560,000 copies/mL). The median CD4 count was 76.0/μL (IQR, 157/μL). Lesions other than those of the skin were observed in the gastrointestinal tract (nine cases, 39.1%), oropharynx (three cases, 13.0%), and bronchial/lung (two cases, 8.7%). The median HHV-8 viral load was 0.0 copies/10

conclusionA high HHV-8 viral load may be a risk factor for mortality in PLWH with KS. Notably, all PLWH diagnosed with KICS in this study died, underscoring the poor prognosis associated with this condition.

Indexed as

Herpesvirus 8, HumanHIV InfectionsSarcoma, KaposiViral LoadAdultFemaleHumansJapanMaleMiddle AgedPrognosisRetrospective StudiesAIDSHIVKaposi sarcomaKaposi sarcoma inflammatory cytokine syndrome

Identifiers

PMID41754504
PMCPMC12945237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.