Evidence map›Paper›PMID 41754463›Full record

ArticlePathogens (Basel, Switzerland)2026

A Nested PCR-Based Point of Care Testing of Multiplex Pathogens Associated with Bloodstream Infection.

Shihao Jiao, Juntao Meng, Jianing Wu, Duoxiao Zhang, Xingyu Liu, Zhiqiang Han, Yuxin Wang, Shijue Gao, Zijin Zhao, Yujie Xiang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shihao JiaoGraduate School, North China University of Science and Technology, Tangshan 063210, China.
Juntao MengDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Jianing WuDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Duoxiao ZhangDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.ORCID 0009-0000-7014-0277
Xingyu LiuDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Zhiqiang HanDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Yuxin WangDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Shijue GaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zijin ZhaoDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Yujie XiangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Junkai RenNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Qian MaDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Xinxin LiDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.
Xinxin ShenNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Xuejun MaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Yanqing TieDepartment of Clinical Laboratory, Hebei General Hospital, Shijiazhuang 050051, China.

Funding

Beijing Medical Award Foundation YXTL-2024-0002-0600Government funded clinical medical talents training project ZF2026031Hebei Province Medical Science Research Project 20260005National Natural Science Foundation of China 82202593
6 · The paper itself

Abstract

Bloodstream infections (BSI) carry high mortality, but traditional blood culture is too slow for urgent clinical needs. This study aims to develop a rapid point-of-care testing assay based on one-tube multiplex nested polymerase chain reaction (PCR) (OM-NPCR-POCT) for early diagnosis of three pathogens in bloodstream infection patients:

Indexed as

BacteremiaMultiplex Polymerase Chain ReactionPoint-of-Care TestingPolymerase Chain ReactionSepsisEscherichia coliHumansKlebsiella InfectionsKlebsiella pneumoniaeRapid Diagnostic TestsSensitivity and SpecificityStreptococcus pneumoniaebloodstream infectionEscherichia coliKlebsiella pneumoniaemultiple detectionnested PCRpoint-of-care testingStreptococcus pneumoniae

Identifiers

PMID41754463
PMCPMC12943058

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.