ArticlePathogens (Basel, Switzerland)2026
Discovery of Novel c-di-GMP-Related Genes in
Anielle Salviano de Almeida Ferrari, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Gabriela Roberto Silva, Cauê Augusto Boneto Gonçalves, Daniel Enrique Sanchez-Limache, Bruna Sayuri Cardoso Ogusku, Anacleto Silva de Souza, Robson Francisco de Souza, Cristiane Rodrigues Guzzo
Abstract read
In one paragraphArticle in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Anielle Salviano de Almeida FerrariDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-7072-4846 Davi Gabriel Salustiano MerighiDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0001-6897-2955 Aline Biazola VisnardiDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Gabriela Roberto SilvaDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Cauê Augusto Boneto GonçalvesDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-1091-5581 Daniel Enrique Sanchez-LimacheDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0003-1364-7527 Bruna Sayuri Cardoso OguskuDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0009-0005-6610-0068 Anacleto Silva de SouzaDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-5669-1723 Robson Francisco de SouzaDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-5284-4630 Cristiane Rodrigues GuzzoDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-5664-8055 Funding
FAPESP 2019/00195-2, 2020/04680-0, 2016/09047-8, 2022/08730-7, 2017/17303-7, 2021/10577-0, 2021/05262-0, 2017/17303-7, 2017/06394-1, 2024/10763-6, 2023/10432-7, 2022/04601-8, 2023/13894-1, 2023/18211-0, 2021/10577-0FAPESP 2025/02664-0
6 · The paper itselfAbstract
Cyclic di-GMP (bis-(3'→5') cyclic dimeric guanosine monophosphate) is a ubiquitous bacterial second messenger that regulates a wide range of cellular processes, including biofilm formation, motility, virulence, and environmental adaptation. Its intracellular levels are dynamically controlled by diguanylate cyclases (DGCs), which synthesize c-di-GMP from GTP, and phosphodiesterases (PDEs), which degrade it into linear pGpG or GMP. The functional effects of cytoplasmic c-di-GMP are mediated through diverse effector proteins, including PilZ domain-containing receptors, transcription factors, and riboswitches. In
Indexed as
Cyclic GMPLeptospira interrogansBacterial ProteinsComputational BiologyEscherichia coli ProteinsGene Expression Regulation, BacterialHumansLeptospirosisPhosphoric Diester HydrolasesPhosphorus-Oxygen LyasesBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPdiguanylate cyclaseEscherichia coli ProteinsPhosphoric Diester HydrolasesPhosphorus-Oxygen Lyasesc-di-GMP receptorsEALGGDEFHD-GYPPilZ
Identifiers
PMID41754404
PMCPMC12943098
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