Evidence map›Paper›PMID 41754223›Full record

ArticleNutrients2026

Association Between Nutritional Status and Extranodal Extension of Lymph Node Metastases in Head and Neck Squamous Cell Cancers.

Kornél Dános, Mátyás Majoros, Lili Tóth, Benedek Besenczi, Mohammad Aouf, Angéla Horváth, László Tamás, Imre Uri

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Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kornél DánosDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-3829-8266
Mátyás MajorosDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.
Lili TóthDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.
Benedek BesencziDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.ORCID 0009-0004-2508-6418
Mohammad AoufDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-5427-5419
Angéla HorváthDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-0023-1816
László TamásDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0003-3723-9149
Imre UriDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery, Semmelweis University, 1085 Budapest, Hungary.ORCID 0009-0008-4352-9066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExtranodal extension (ENE) is a well-established adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC), associated with reduced survival and the need for intensified therapy. Nutritional status-commonly assessed using the Prognostic Nutritional Index (PNI) and Body Mass Index (BMI)-also influences outcomes in HNSCC. However, whether or not ENE correlates with nutritional status has not been previously investigated.

methodsWe conducted a retrospective cohort study of 109 treatment-naïve HNSCC patients with pathologically confirmed nodal metastases who underwent primary tumor resection and neck dissection between 2014 and 2025 at a national tertiary center. ENE status was determined histologically. Nutritional status was evaluated using BMI, PNI, serum albumin, and percentage of weight loss at diagnosis. Statistical analyses included

resultsENE was present in 54.1% of patients and significantly reduced overall survival (Kaplan-Meier

conclusionsENE is a strong prognostic marker in HNSCC, appearing to be independent of nutritional status. The demonstrated heterogeneity of ENE prevalence among tumor subsites supports the need for individualized management approaches.

Indexed as

Extranodal ExtensionHead and Neck NeoplasmsLymphatic MetastasisNutritional StatusSquamous Cell Carcinoma of Head and NeckAgedBody Mass IndexFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNutrition AssessmentPrognosisRetrospective Studiesbody mass index (BMI)extranodal extension (ENE)head and neck squamous cell carcinoma (HNSCC)prognostic nutritional index (PNI)

Identifiers

PMID41754223
PMCPMC12943534

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