Evidence map›Paper›PMID 41754168›Full record

Trial reportNutrients2026

Effect of Perioperative Supplementation with Arginine and Omega-3 on Postoperative Complications in Patients Undergoing Gastrointestinal Cancer Surgery: A Pilot Open-Label Randomized Controlled Trial.

Saida Sakhri, Rym Ben Othman, Chaima Jerbi, Halil İbrahim Ceylan, Lamia Naija, Ines Zemni, Henda Jamoussi, Tarek Ben Dhiab, Nagihan Burçak Ceylan, Valentina Stefanica and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Saida SakhriDepartment of Surgical Oncology, Salah Azaiez Institute, Tunis 1007, Tunisia.ORCID 0000-0003-2518-3555
Rym Ben OthmanNational Institute of Nutrition and Food Technology, Tunis 1007, Tunisia.ORCID 0000-0002-2453-9778
Chaima JerbiHigher School of Health Sciences and Techniques of Tunis, University of Tunis El Manar, Tunis 1007, Tunisia.
Halil İbrahim CeylanPhysical Education and Sports Teaching Department, Faculty of Sports Sciences, Atatürk University, Erzurum 25240, Türkiye.ORCID 0009-0005-2214-4667
Lamia NaijaDepartment of Surgical Oncology, Salah Azaiez Institute, Tunis 1007, Tunisia.
Ines ZemniDepartment of Surgical Oncology, Salah Azaiez Institute, Tunis 1007, Tunisia.
Henda JamoussiFaculty of Medicine of Tunis, University of Tunis El Manar, Tunis 1007, Tunisia.ORCID 0000-0002-8215-3718
Tarek Ben DhiabDepartment of Surgical Oncology, Salah Azaiez Institute, Tunis 1007, Tunisia.
Nagihan Burçak CeylanGraduate Education Institute, Bayburt University, Bayburt 69000, Türkiye.
Valentina StefanicaDepartment of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, 060042 Pitesti, Romania.ORCID 0000-0003-4031-1412
Ismail DergaaHigh Institute of Sport and Physical Education of Ksar Said, University of Manouba, Mannouba 2010, Tunisia.ORCID 0000-0001-8091-1856

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerioperative immunonutrition, including arginine and omega-3 fatty acids, has been proposed to support postoperative recovery by modulating immune function.

aimTo evaluate the effects of perioperative arginine and omega-3 supplementation on postoperative infectious complications, mortality, hospital length of stay, intensive care unit duration, and inflammatory markers in patients undergoing gastrointestinal cancer surgery.

methodsIn this Pilot Open-Label randomized trial, 35 adult patients scheduled for elective gastrointestinal cancer surgery at Salah Azaiez Institute were randomly assigned to receive either perioperative immunonutrition (n = 18; three daily capsules of omega-3 and one sachet of Arginine+ for 7 days preoperatively and 7 days postoperatively) or standard care (n = 17). Primary endpoints were postoperative infectious complications and 1-month mortality. Secondary endpoints included hospital length of stay, ICU duration, and postoperative biochemical markers.

resultsNo statistically significant differences were observed between groups in 1-month mortality (

conclusionsIn this trial, perioperative immunonutrition with arginine and omega-3 fatty acids did not improve postoperative clinical outcomes or inflammatory markers in patients undergoing gastrointestinal cancer surgery. At the administered dose and within a small, heterogeneous cohort, immunonutrition did not provide additional benefit beyond standard care. Larger, adequately powered multicenter trials with optimized dosing are required to clarify its role in gastrointestinal oncology.

Indexed as

ArginineDietary SupplementsDigestive System Surgical ProceduresFatty Acids, Omega-3Gastrointestinal NeoplasmsPerioperative CarePostoperative ComplicationsAgedFemaleHumansImmunonutrition DietLength of StayMaleMiddle AgedPilot ProjectsTreatment OutcomeArginineFatty Acids, Omega-3complicationsgastrointestinal cancerimmunonutritiononcological surgerypostoperative outcomessurgical complicationssurgical site infectionswound infections

Identifiers

PMID41754168
PMCPMC12942923

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.