ArticleMicroorganisms2026
Common Serum Biomarkers and Combination Ratios in the Diagnosis of Periprosthetic Joint Infection Following Total Hip Arthroplasty.
Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The diagnostic value of platelet-related indicators to CRP ratio in periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate preoperative diagnosis of periprosthetic joint infection (PJI) is difficult, complicating distinction between septic and aseptic failures. This study assessed the value of common serum biomarkers and three calculated ratios-albumin-globulin ratio (AGR), C-reactive protein-albumin ratio (CAR), and C-reactive protein-AGR ratio (CAGR)-in diagnosing PJI after primary total hip arthroplasty (THA). We retrospectively reviewed patients undergoing revision THA for PJI or aseptic failure from 2011 to 2021 at a single institution. Inclusion required reported serum white blood cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin (Alb), and total protein (TP). Diagnostic performance was evaluated using areas under the curve (AUCs), with higher values indicating better accuracy. Ratios were defined as: AGR = Alb/[TP - Alb], CAR = CRP/Alb, and CAGR = CRP/AGR. Among 128 cases, 67 were PJI and 61 aseptic. AUCs were: WBC (0.53), CRP (0.69), ESR (0.75), Alb (0.69), Glb (0.63), TP (0.53), AGR (0.72), CAR (0.70), and CAGR (0.71). Optimal cutoff, sensitivity, and specificity were: CRP (10.5, 0.76, 0.59), ESR (41.0, 0.70, 0.72), AGR (1.10, 0.64, 0.75), CAR (3.37, 0.73, 0.64), and CAGR (10.9, 0.75, 0.66). ESR, AGR, CAR, and CAGR demonstrated acceptable accuracy. These readily available markers and ratios may aid PJI diagnosis, supporting improved clinical decision-making.
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