Evidence map›Paper›PMID 41752947›Full record

ArticleLife (Basel, Switzerland)2026

Increased Risk of Recurrent Ischemic Stroke in Male Patients Taking Medications for Benign Prostatic Hyperplasia.

Chun-Gu Cheng, Chun-Fang Chen, Wu-Chien Chien, Chia-Chao Wu, Hung-Wen Chiu, Fei-Hung Hung, Hung-Pin Peng, Chi-Hsiang Chung, Chun-An Cheng

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Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chun-Gu ChengDepartment of Emergency Medicine, Taoyuan Armed Forces General Hospital, Taoyuan 32549, Taiwan.ORCID 0000-0002-1081-760X
Chun-Fang ChenDepartment of Emergency Medicine, Cheng Hsin General Hospital, Taipei 11220, Taiwan.
Wu-Chien ChienSchool of Public Health, National Défense Medical University, Taipei 11490, Taiwan.ORCID 0000-0002-3286-0780
Chia-Chao WuDepartment of Nephrology, College of Medicine, Tri-Service General Hospital, National Défense Medical University, Taipei 11490, Taiwan.ORCID 0000-0002-8772-011X
Hung-Wen ChiuGraduate Institute of Biomedical Informatics, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-6919-8199
Fei-Hung HungHealth Data Analytics and Statistics Centre, Office of Data Science, Taipei Medical University, New Taipei City 235041, Taiwan.ORCID 0000-0001-9453-916X
Hung-Pin PengResearch Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, New Taipei City 235041, Taiwan.ORCID 0000-0002-9398-8120
Chi-Hsiang ChungSchool of Public Health, National Défense Medical University, Taipei 11490, Taiwan.ORCID 0000-0002-4576-9900
Chun-An ChengDepartment of Neurology, College of Medicine, Tri-Service General Hospital, National Défense Medical University, Taipei 11490, Taiwan.ORCID 0000-0002-0380-7286

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with benign prostatic hyperplasia (BPH) have an increased risk of developing cardiovascular disease. Taking alpha-1 blockers is associated with an increased risk of major adverse cardiovascular events. Patients suffering from ischemic stroke (IS) may develop baroreflex and parasympathetic dysfunction-induced cerebral autoregulation impairment. The relationship between pharmacotherapy for BPH and the risk of recurrent IS remains unclear. The purpose of this study was to determine whether medications for BPH increase the risk of recurrent IS.

methodsThis is a retrospective cohort study. Data from patients diagnosed with IS between 2000 and 2015 was collected from Taiwan National Health Insurance Database. Newly diagnosed IS patients were identified (International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM): 433-437). BPH patients with an ICD-9-CM of 600 were identified. The event observed was recurrent IS after the firstever IS. The factors associated with recurrent IS were assessed via Cox proportional hazards regression.

resultsRecurrent IS was associated with BPH with an adjusted hazard ratio (HR) of 1.505 and a 95% confidence interval (CI) of 1.112-1.829,

conclusionsThese findings highlight the association between BPH incidence and the risk of recurrent IS. The pharmacotherapy for BPH in IS patients should take great care.

Indexed as

alpha-1 adrenergic blockerbenign prostatic hyperplasiarecurrent ischemic stroke

Identifiers

PMID41752947
PMCPMC12942141

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