Erectile and Clitoral Dysfunction as Harbingers of Cardiovascular Disease: A Perspective.

Fernanda Priviero, Fiona Hollis, Susan K Wood, Mark Uline, Karl-Erik Andersson, R Clinton Webb

Abstract readReview

In one paragraph

Review in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fernanda PrivieroCardiovascular Translational Research Center, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-6022-2081

Fiona HollisDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0001-6559-5736

Susan K WoodDepartment of Pharmacology, Physiology and Neuroscience, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0001-5732-3335

Mark UlineDepartment of Biomedical Engineering, University of South Carolina, Columbia, SC 29208, USA.ORCID 0000-0002-3533-871X

Karl-Erik AnderssonDivision of Clinical Chemistry and Pharmacology, Lund University, 221 00 Lund, Sweden.ORCID 0000-0003-0665-3486

R Clinton WebbCardiovascular Translational Research Center, University of South Carolina, Columbia, SC 29208, USA.ORCID 0009-0009-9403-305X

Funding

Psychosocial stress-induced neurometabolic dysfunction as a mediator ofpostpartum cardiovascular diseaseR01HL179186 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Fiona E. Hollis, Susan Kathleen Wood · 2025 to 2026

$1.4M

BLRD VA I21 BX006218Institute for Cardiovascular Disease Research from University South Carolina Office of the Vice President for Research N/AISSWSH N/ANHLBI NIH HHS R01 HL179186NIH HHS 1R01DK132948-22Sexual Medicine Society of North America N/AUnited States Department of Defense N/A

6 · The paper itself

Abstract

Sexual dysfunction (SD), more specifically vasculogenic erectile dysfunction (ED) in men and female sexual arousal disorder (FSAD) in women, is increasingly recognized as a marker of cardiovascular disease (CVD). While extensive literature documents vasculogenic ED as an early warning sign of coronary artery disease (CAD) and other atherosclerotic manifestations, the evidence for analogous phenomena in women is emerging but less mature. This perspective explores epidemiologic associations, shared pathophysiologic mechanisms, clinical implications, and screening paradigms for ED and FSAD as cardiovascular (CV) risk-enhancing conditions. This perspective endorses that clinicians should incorporate genital vasculogenic SD into CV risk stratification and that multidisciplinary care (primary care, cardiology, urology/gynecology) is warranted. A summary table outlines key features and actionable steps.

Indexed as

Cardiovascular DiseasesClitorisErectile DysfunctionSexual Dysfunction, PhysiologicalFemaleHumansMaleRisk Factorsclitoriserectile dysfunctionfemale sexual arousal disorderfemale sexual dysfunctionpenissexual dysfunction

Identifiers

PMID41752814

DOI10.3390/medicina62020416

PMCPMC12943142

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.