Brain-Derived Neurotrophic Factor Deficiency Exacerbates Innate Immune Responses by Enhancing NLRP3 Inflammasome Activation and GSDMD-Mediated Pyroptosis in Mice.

Şeniz Erdem, Neslihan Sağlam, Elif Şahin, Mehmet Erdem, İsmail Abidin, Ahmet Alver

Abstract read

In one paragraph

Article in Medicina (Kaunas, Lithuania), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Şeniz ErdemDepartment of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye.

Neslihan SağlamDepartment of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye.

Elif ŞahinDepartment of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye.

Mehmet ErdemDepartment of Medical Biochemistry, Faculty of Medicine, Malatya Turgut Özal University, Malatya 44210, Türkiye.ORCID 0000-0002-9100-2479

İsmail AbidinDepartment of Biophysics, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye.

Ahmet AlverDepartment of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Türkiye.

Funding

Scientific Research Projects Coordination Unit of Karadeniz Technical University TDK-2021-9686 and TSA-2023-10700

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain-Derived Neurotrophic FactorImmunity, InnateInflammasomesIntracellular Signaling Peptides and ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding ProteinsPyroptosisAnimalsGasderminsLipopolysaccharidesMaleMiceNF-kappa BBdnf protein, mouseBrain-Derived Neurotrophic FactorGasderminsGsdmd protein, mouseInflammasomesIntracellular Signaling Peptides and ProteinsLipopolysaccharidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePhosphate-Binding ProteinsBDNFESCRT-III machineryNLRP3 inflammasomepyroptosisselective autophagy

Identifiers

PMID41752782

DOI10.3390/medicina62020384

PMCPMC12941858

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.