ArticleInsects2026
Dopamine Enhances Healthspan and Locomotor Performance via Antioxidant Defense in Silkworms,
Article in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The impact of dopamine on aging is complex and context-dependent. This study systematically investigated the effects of dopamine levels on the lifespan and behavior of the silkworm moth by employing genetic mutants of the dopamine synthesis/metabolic pathway combined with pharmacological interventions. The results demonstrated a significant positive correlation between endogenous dopamine levels and adult lifespan. Reducing dopamine levels shortened lifespan, whereas a moderate peripheral administration significantly extended healthspan, improved locomotor activity, and restored motor vigor in aged moths, though an excessive dose was toxic. The lifespan-extending effect of dopamine was closely correlated with enhanced total antioxidant capacity, observed in both long-lived strains and dopamine-treated individuals. Dopamine's effects also exhibited sexual dimorphism and age dependency. This research reveals that a moderate increase in systemic endogenous dopamine or peripheral dopamine administration exerts positive effects on lifespan and aging-related behaviors, an effect likely mediated by enhanced antioxidant defense. These findings not only advance our understanding of the role of dopamine in the aging process but also provide a novel theoretical framework for developing anti-aging therapies and breeding superior silkworm strains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.