Evidence map›Paper›PMID 41752569›Full record

ArticleInsects2026

Sublethal Pyriproxyfen Exposure Alters

Simoni Twaha Mnzava, Augustino Thabiti Mmbaga, Anitha Mutashobya, Letus Laurian Muyaga, Mwema Felix Mwema, Halfan Ngowo, Dickson Wilson Lwetoijera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simoni Twaha MnzavaEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania.
Augustino Thabiti MmbagaEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania.
Anitha MutashobyaEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania.
Letus Laurian MuyagaEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania.
Mwema Felix MwemaSchool of Materials, Energy, Water and Environmental Sciences, The Nelson Mandela African Institution of Science and Technology, Arusha P.O. Box 447, Tanzania.ORCID 0009-0007-1084-2497
Halfan NgowoEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania.
Dickson Wilson LwetoijeraEnvironmental Health and Ecological Sciences Department, Ifakara Health Institute, Ifakara P.O. Box 53, Tanzania.ORCID 0000-0003-2544-0451

Funding

This study was funded by the National Institute for Health Research (NIHR) (using the UK's Official Development Assistance (ODA) funding) and Wellcome [218776/Z/19/Z] through the NIHR-Wellcome Partnership for Global Health Research. 218776/Z/19/Z
6 · The paper itself

Abstract

backgroundPyriproxyfen (PPF), a juvenile hormone analog, is a promising chemical for autodissemination strategies, where mosquitoes aid in transferring insecticides to their breeding sites. This study evaluated the effects of sublethal PPF doses on

methodsLaboratory-reared, pyrethroid-resistant mosquito larvae were exposed once to sublethal PPF concentrations of (0.0003, 0.0006, 0.0008, and 0.001 mg a.i./L), which caused emergence inhibition rates of 5%, 10%, 15%, and 20%, respectively, alongside a control group. Emerged adults were tested for susceptibility to 0.75% permethrin, 3.75% permethrin, and 0.05% deltamethrin using WHO tube bioassays. Knockdown was recorded at 1 h, mortality at 24 h post-exposure, while fecundity, fertility, and body size were measured across three generations.

resultsFirst-generation

conclusionsThese findings suggest that sublethal PPF doses can temporarily enhance insecticide resistance without leading to heritable resistance and negatively impact key mosquito fitness traits. PPF may thus be a valuable addition to integrated vector management strategies.

Indexed as

Anopheles arabiensisautodisseminationinsecticidespyrethroidspyriproxyfensemi-field settingssublethal dose

Identifiers

PMID41752569
PMCPMC12940566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.