Identification of Steroidal Alkaloids with In Vitro Antiprotozoal Activity from

Justus Wambua Mukavi, Monica Cal, Marcel Kaiser, Pascal Mäser, Njogu M Kimani, Leonidah Kerubo Omosa, Thomas J Schmidt

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justus Wambua MukaviUniversity of Münster, Institute of Pharmaceutical Biology and Phytochemistry (IPBP), PharmaCampus, Corrensstraße 48, D-48149 Münster, Germany.ORCID 0000-0001-9638-3250

Monica CalSwiss Tropical and Public Health Institute (Swiss TPH), Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.

Marcel KaiserSwiss Tropical and Public Health Institute (Swiss TPH), Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.ORCID 0000-0003-1785-7302

Pascal MäserSwiss Tropical and Public Health Institute (Swiss TPH), Kreuzstrasse 2, CH-4123 Allschwil, Switzerland.ORCID 0000-0003-3122-1941

Njogu M KimaniDepartment of Physical Sciences, University of Embu, P.O. Box 6, Embu 60100, Kenya.ORCID 0000-0002-5171-1940

Leonidah Kerubo OmosaDepartment of Chemistry, Faculty of Science & Technology, University of Nairobi, P.O. Box 30197, Nairobi 00100, Kenya.ORCID 0000-0002-5821-8307

Thomas J SchmidtUniversity of Münster, Institute of Pharmaceutical Biology and Phytochemistry (IPBP), PharmaCampus, Corrensstraße 48, D-48149 Münster, Germany.ORCID 0000-0003-2634-9705

Funding

Apothekerstiftung Westfalen-Lippe Project title: "Struktur-Wirkungsbeziehungen für die antiprotozoale Aktivität von Aminosteroiden und Amino-nortriterpenen aus Buxaceae und Apocynaceae"; no grant numberNational Research Fund-Kenya, in cooperation with the German Academic Exchange Service (NRF-DAAD) Doctoral fellowship for Justus Wambua Mukavi; no grant number.

6 · The paper itself

Abstract

Human African Trypanosomiasis (HAT) and Malaria are serious infectious diseases endemic in tropical regions, caused by protozoan parasites, and necessitating an urgent development of new antiprotozoal drugs. As part of our ongoing search for new antiprotozoal steroidal alkaloids from plants, we investigated the methanolic stem bark extract of

Indexed as

AlkaloidsAntiprotozoal AgentsHolarrhenaPlant ExtractsSteroidsAnimalsChromatography, High Pressure LiquidPlant BarkPlasmodium falciparumTrypanosoma brucei rhodesienseAlkaloidsAntiprotozoal AgentsPlant ExtractsSteroidsApocynaceaecentrifugal partition chromatography (CPC)Holarrhena pubescens Wall. ex G. Donnatural productspartial least squares (PLS) regressionPlasmodium falciparumsteroidal alkaloidsTrypanosoma brucei rhodesiense

Identifiers

PMID41752510

DOI10.3390/molecules31040733

PMCPMC12942945

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.