Evidence map›Paper›PMID 41752374›Full record

ArticleMolecules (Basel, Switzerland)2026

Design and Synthesis of Tacrine-Coumarin Hybrids via Click Chemistry as Multifunctional Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease.

Xiaohua Wang, Xueliang Lu, Wanwan Jin, Xiaoyan Tan, Gang Wang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaohua WangSynergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.ORCID 0000-0002-6867-1893
Xueliang LuSchool of Chemistry and Environmental Engineering, Key Laboratory of Green Chemical Engineering Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430205, China.
Wanwan JinSynergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.
Xiaoyan TanSynergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.
Gang WangSynergy Innovation Center of Biological Peptide Antidiabetics of Hubei Province, College of Life Science, Wuchang University of Technology, Wuhan 430223, China.ORCID 0000-0002-0358-2347

Funding

the Research and Development Fund of Wuchang University of Technology X2024ZZ001
6 · The paper itself

Abstract

A new series of tacrine-coumarin hybrids (compounds

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsCoumarinsDrug DesignTacrineAcetylcholinesteraseAmyloid beta-PeptidesButyrylcholinesteraseClick ChemistryHumansMolecular StructureMonoamine OxidaseMonoamine Oxidase InhibitorsProtein AggregatesStructure-Activity RelationshipAcetylcholinesteraseAmyloid beta-PeptidesButyrylcholinesteraseCholinesterase InhibitorscoumarinCoumarinsMonoamine OxidaseMonoamine Oxidase InhibitorsProtein AggregatesTacrineacetylcholinesteraseAlzheimer’s diseasebutyrylcholinesteraseMAO-B inhibitormultitarget-directed ligand

Identifiers

PMID41752374
PMCPMC12943243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.