ArticleInternational journal of molecular sciences2026
Clinical Characteristics and Gene Expression of JAK2, STAT3, miRNA-155, and miRNA-216a in Young Adults with Acute Ischemic Stroke.
David Vidal-González, Jazmin Marquez-Pedroza, Betsabé Contreras-Haro, Ana Miriam Saldaña-Cruz, Carlos Fernando Godínez-González, Antonio Kobayashi-Gutiérrez, Nayeli Alejandra Sánchez-Rosales, Edgar Ricardo Valdivia-Tangarife, José de Jesús García-Rivera, Idarmis Brisseida Reyes-Cortés and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
David Vidal-GonzálezHigh Specialty Medical Unit, Department of Neurology, Western National Medical Center of the Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-2112-3141 Jazmin Marquez-PedrozaNeurosciences Division, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-2859-726X Betsabé Contreras-HaroDepartment of Biomedical Sciences, Tonala University Center, University of Guadalajara, Tonala 45425, Mexico.
Ana Miriam Saldaña-CruzPhysiology Department, Institute of Experimental and Clinical Therapeutics, University Center for Health Sciences, University of Guadalajara, Guadalajara 44340, Mexico.ORCID 0000-0003-2272-9612 Carlos Fernando Godínez-GonzálezHigh Specialty Medical Unit, Department of Neurology, Western National Medical Center of the Mexican Institute of Social Security, Guadalajara 44340, Mexico.
Antonio Kobayashi-GutiérrezHigh Specialty Medical Unit, Department of Neurology, Western National Medical Center of the Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0002-5540-1923 Nayeli Alejandra Sánchez-RosalesHigh Specialty Medical Unit, Department of Neurology, Western National Medical Center of the Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-4297-7111 Edgar Ricardo Valdivia-TangarifeDepartment of Neurosciences, University Center for Health Sciences, University of Guadalajara, Guadalajara 44340, Mexico.ORCID 0000-0002-0936-7525 José de Jesús García-RiveraHigh Specialty Medical Unit, Department of Neurology, Western National Medical Center of the Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0001-7393-921X Idarmis Brisseida Reyes-CortésHigh Specialty Medical Unit, Department of Neurology, Western National Medical Center of the Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-0342-5330 Blanca Miriam Torres-MendozaNeurosciences Division, Western Biomedical Research Center, Mexican Institute of Social Security, Guadalajara 44340, Mexico.ORCID 0000-0003-2233-571X Martha Rocio Hernández-PreciadoDepartment of Philosophical, Methodological and Instrumental Disciplines, University Health Sciences Center, University of Guadalajara, Guadalajara 44340, Mexico.ORCID 0000-0003-4757-4792 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Acute ischemic stroke (AIS) is a leading cause of long-term disability and death. The genetic, epigenetic, and molecular mechanisms underlying AIS in young adults require further investigation. Inflammatory pathways, such as the programmed death-ligand 1 (PD-L1) and the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway, are implicated in promoting post-ischemic neuroinflammation and neuronal apoptosis. While miR-155 and miR-216a are mediators of inflammation, apoptosis, and tissue repair following AIS. This exploratory study aimed to analyze the expression of the JAK2/STAT3, miR-155, and miR-216a genes in young AIS patients (mean age: 39.4 ± 11.9 years) versus the healthy population (HP). Peripheral blood samples were collected, and gene and miRNA expressions were measured using quantitative real-time PCR. Our results showed that stroke patients exhibited overexpression of all genes (
Indexed as
Brain IschemiaIschemic StrokeJanus Kinase 2MicroRNAsSTAT3 Transcription FactorStrokeAdultBiomarkersFemaleGene Expression RegulationHumansMaleMiddle AgedBiomarkersJAK2 protein, humanJanus Kinase 2MicroRNAsMIRN155 microRNA, humanMIRN216 microRNA, humanSTAT3 protein, humanSTAT3 Transcription Factoracute ischemic strokesgene expressionischemic stroke
Identifiers
PMID41752127
PMCPMC12940177
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