Evidence map›Paper›PMID 41752101›Full record

ArticleInternational journal of molecular sciences2026

Benchmarking

Iraia Muñoa-Hoyos, Manu Araolaza, Irune Calzado, Mikel Albizuri, Nerea Subirán

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iraia Muñoa-HoyosDepartment of Nursing I, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Bizkaia, Spain.ORCID 0000-0002-5107-6991
Manu AraolazaDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Bizkaia, Spain.ORCID 0000-0003-1838-4594
Irune CalzadoDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Bizkaia, Spain.ORCID 0000-0002-1787-6792
Mikel AlbizuriDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Bizkaia, Spain.ORCID 0009-0008-5484-7414
Nerea SubiránDepartment of Physiology, Faculty of Medicine and Nursing, University of the Basque Country, 48940 Leioa, Bizkaia, Spain.ORCID 0000-0001-9202-1287

Funding

Basque Government, Department of Education IT1547-22European Union (ERDF/ESF, "Investing in your future" PI20/01131Instituto de Salud Carlos III CPP2021-008458Instituto de Salud Carlos III PID2020-119949RB-100Ministry of Science and Innovation PID2020-119949RB-100
6 · The paper itself

Abstract

Despite the improvements in tool development for DNA methylation analysis, there is a lack of a consensus on computational and statistical models used for differentially methylated cytosine (DMC) identification. This variability complicates the interpretation of findings and raises concerns about the reproducibility and biological significance of the detected results. In this regard, here we conducted a comparative evaluation of

Indexed as

Computational BiologyDNA MethylationSoftwareAnimalsBenchmarkingCpG IslandsMiceMouse Embryonic Stem CellsReproducibility of Resultsbioinformatics pipelinesdifferential methylation cytosinesdifferential methylation genesDNA methylationedgeRmethylKit

Identifiers

PMID41752101
PMCPMC12941088

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.