Novel Small-Molecule Analogues of IU1 Ameliorate Amyloid-β Mediated Toxicity in Alzheimer's Disease Cell and Worm Models.

Ajish Ariyath, Fraulein Denise Arigo, Izhar Wallach, W M A D Binosha Fernando, Ralph N Martins, Prashant Bharadwaj

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The Poly-Arginine Peptide R18D Inhibits Amyloid-Beta (Aβ) Aggregation and Aβ-Induced Cytotoxicity, Reduces Intracellular Tau Aggregation, and Exhibits Oral Bioavailability.Biomedicines · 2026
Article
A High-Throughput Assay for Monitoring and Quantifying Amyloid-β Accumulation and Clearance in Alzheimer's Disease Cell Models.Journal of neurochemistry · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ajish AriyathCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia.

Fraulein Denise ArigoCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia.ORCID 0009-0009-5169-0199

Izhar WallachAtomwise, 250 Sutter St, Suite 650, San Francisco, CA 94108, USA.

W M A D Binosha FernandoCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia.

Ralph N MartinsCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia.

Prashant BharadwajCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Sarich and Patricia Neuroscience Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia.ORCID 0000-0003-4361-9906

Funding

National Foundation for Medical Research and Innovation NANational Health and Medical Research Council APP1107109

6 · The paper itself

Abstract

Dysregulation of the deubiquitinating enzyme Ubiquitin-specific peptidase 14 (USP14) is implicated in several neurodegenerative diseases, and IU1, an allosteric inhibitor, has shown neuroprotective effects by reducing protein aggregate toxicity. This study aimed to develop new IU1 analogues and evaluate their ability to mitigate amyloid-β (Aβ) accumulation and toxicity in Alzheimer's disease (AD) cell and

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesClioquinolNeuroprotective AgentsSmall Molecule LibrariesAnimalsCaenorhabditis elegansDisease Models, AnimalHumansProteasome Endopeptidase ComplexAmyloid beta-PeptidesClioquinolNeuroprotective AgentsProteasome Endopeptidase ComplexSmall Molecule Librariesamyloid precursor proteinamyloid-β proteinartificial intelligencedeubiquitinase enzymeubiquitin–proteasome system

Identifiers

PMID41752099

DOI10.3390/ijms27041963

PMCPMC12940727

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.