Evidence map›Paper›PMID 41752094›Full record

ArticleInternational journal of molecular sciences2026

Vitamin D Receptor (VDR) Polymorphisms and Cardiometabolic Profiles in Orthopedic Patients: A Cluster-Based Analysis.

Dariusz Larysz, Remigiusz Recław, Aleksandra Suchanecka, Wojciech Dziurawiec, Rafał Tkacz, Aleksandra Strońska-Pluta, Krzysztof Chmielowiec, Anna Grzywacz, Jolanta Chmielowiec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dariusz LaryszDepartment of Trauma and Orthopaedic Surgery, 109th Military Hospital with Polyclinic, Ministry of National Defense, ul. Ksiedza Piotra Skargi 9/11, 71-422 Szczecin, Poland.ORCID 0009-0007-4267-2250
Remigiusz RecławIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0009-0004-7841-821X
Aleksandra SuchaneckaIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0002-7137-1429
Wojciech DziurawiecDepartment of Trauma and Orthopaedic Surgery, 109th Military Hospital with Polyclinic, Ministry of National Defense, ul. Ksiedza Piotra Skargi 9/11, 71-422 Szczecin, Poland.ORCID 0009-0001-6011-9383
Rafał TkaczDepartment of Trauma and Orthopaedic Surgery, 109th Military Hospital with Polyclinic, Ministry of National Defense, ul. Ksiedza Piotra Skargi 9/11, 71-422 Szczecin, Poland.ORCID 0009-0001-7091-6829
Aleksandra Strońska-PlutaIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0001-6564-2141
Krzysztof ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.ORCID 0000-0003-4254-5466
Anna GrzywaczIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0002-2633-520X
Jolanta ChmielowiecDepartment of Nursing, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.ORCID 0000-0003-3285-5313

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic polymorphisms contribute to inter-individual variability in cardiometabolic risk and quality-of-life outcomes, yet their clinical relevance often remains unclear due to population heterogeneity and reliance on single-variant analyses. Integrative approaches combining genetic and phenotypic data may improve the characterization of complex disease profiles, particularly in orthopedic populations burdened by cardiometabolic comorbidities. This study included 289 patients scheduled for orthopedic surgery. Polymorphisms in the vitamin D receptor (

Indexed as

Cardiovascular DiseasesPolymorphism, Single NucleotideReceptors, CalcitriolAdultAgedCatechol O-MethyltransferaseCluster AnalysisFemaleHumansMaleMiddle AgedQuality of LifeReceptors, Opioid, muCatechol O-MethyltransferaseCOMT protein, humanOPRM1 protein, humanReceptors, CalcitriolReceptors, Opioid, muVDR protein, humancardiometabolic riskcluster analysisCOMTgenetic polymorphismsOPRM1orthopedic surgeryquality of lifeSF-36vitamin D receptor (VDR)

Identifiers

PMID41752094
PMCPMC12941345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.