Evidence map›Paper›PMID 41752089›Full record

ArticleInternational journal of molecular sciences2026

Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in

Benjamin Hall, Lydia Castelli, Adrian Higginbottom, Jingxuan He, Ling-Nan Zou, Heather Walker, Miriam Yagüe-Capilla, Kari E Wong, David J Burrows, Jonathan George and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Benjamin HallSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Lydia CastelliSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Adrian HigginbottomSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Jingxuan HeDepartment of Chemistry, The Pennsylvania State University, University Park, State College, PA 16802, USA.ORCID 0000-0002-2130-3196
Ling-Nan ZouDepartment of Chemistry, The Pennsylvania State University, University Park, State College, PA 16802, USA.
Heather WalkerbiOMICS Mass Spectrometry Facility, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0002-6815-0465
Miriam Yagüe-CapillaSciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden.ORCID 0000-0002-9643-9960
Kari E WongMetabolon Inc., Morrisville, NC 27560, USA.
David J BurrowsSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Jonathan GeorgeSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Keaton HamerSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Jenny M TannerSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Ergita Kyrgiou-BalliSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0009-0006-7608-9314
Rees RossSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Herbie GarlandSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-7650-0189
Erin TonkissSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Rachel GeorgebiOMICS Mass Spectrometry Facility, Alfred Denny Building, Western Bank, University of Sheffield, Sheffield S10 2TN, UK.ORCID 0000-0001-9257-7197
Christopher P WebsterSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Emma F SmithSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Hannah O TimmonsSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0009-0009-0202-2434
Jess AllsopSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Nikolas StefanidisSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0009-0009-7311-4977
Billie D WardSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Ya-Hui LinSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
J Robin HighleySheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Mimoun AzzouzSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Ryan J H WestSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0001-9873-2258
Sean G RuddSciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, 171 64 Stockholm, Sweden.ORCID 0000-0002-4368-3855
Kurt J De VosSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
Pamela J ShawSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-8925-2567
Guillaume M HautbergueSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0002-1621-261X
Scott P AllenSheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.ORCID 0000-0003-4418-7375

Funding

Academy of Medical Sciences SBF005\1064Alzheimer's Research UK ARUK-PG2018B-005Alzheimer's Society 260 (AS-PG-15-023)Medical Research Council MR/M013251/1Medical Research Council MR/S025979/1Medical Research Council MR/W00416X/1Medical Research Council MR/Z504701/1MND Association Allen 887-791MND Association Allen/Jun23/964-793MND Association AMBRoSIA PJS 972-797MND Association DEVOS/APR18/862-79MND Association West/Oct22/909-792NIHR BRC-203321NIHR NF-SI-0617-10077Swedish Cancer Society 19-0056-JIASwedish Cancer Society 23-2782-PjSwedish Childhood Cancer Fund TJ2022-0063
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the death of motor neurons leading to paralysis and death, generally 3-5 years post-symptom onset. The most frequent genetic cause of ALS is a hexanucleotide repeat expansion (HRE) in the chromosome 9 open reading frame 72 (

Indexed as

Adenosine DeaminaseAmyotrophic Lateral SclerosisC9orf72 ProteinDipeptidesPurinesAnimalsAstrocytesHumansAdenosine DeaminaseC9orf72 ProteinC9orf72 protein, humanDipeptidesPurinesADAALSastrocyteC9orf72DPRmetabolomicsMNDpurine metabolismpurinosome

Identifiers

PMID41752089
PMCPMC12940700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.