Evidence map›Paper›PMID 41752084›Full record

ReviewInternational journal of molecular sciences2026

High-Throughput Sequencing Decodes tsRNA Landscapes: Insights into Cancer Biomarkers and Therapeutic Targets.

Miaoyan Pu, Luyu Shi, Chuanlin Shen, Haimei Cheng, Weijie Ding, Jiaxin Tian, Junhong Ye, Youquan Bu, Ying Zhang

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miaoyan PuDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Luyu ShiDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Chuanlin ShenDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Haimei ChengDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Weijie DingDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Jiaxin TianThe First Clinical College, Chongqing Medical University, Chongqing 400016, China.
Junhong YeDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0003-1501-0263
Youquan BuDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.
Ying ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-5414-6617

Funding

National Natural Science Foundation of China 82403031,82372630Natural Science Foundation of Chongqing, China CSTB2022NSCQ-MSX0123
6 · The paper itself

Abstract

Transfer RNA-derived small RNAs (tsRNAs) represent an emerging category of small non-coding RNAs generated through specific cleavage of precursor or mature tRNAs. Increasingly recognized as pivotal players in the pathogenesis of complex malignancies, tsRNAs not only regulate cancer progression but also hold promising clinical potential for cancer diagnosis and treatment. This review highlights recent advances in the application of high-throughput sequencing technologies in the systematic identification of tsRNAs, with a focus on their roles in cancer diagnosis, prognostic assessment, and targeted therapy. Delving into the translational medicine dimensions of tsRNAs may provide novel strategies for molecular diagnosis and therapeutic interventions in oncology.

Indexed as

Biomarkers, TumorHigh-Throughput Nucleotide SequencingNeoplasmsRNA, Small UntranslatedRNA, TransferAnimalsGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyBiomarkers, TumorRNA, Small UntranslatedRNA, Transferbiomarkercancerhigh-throughput sequencingtherapeutic targettsRNAs

Identifiers

PMID41752084
PMCPMC12940667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.