Evidence map›Paper›PMID 41752072›Full record

ArticleInternational journal of molecular sciences2026

In Vitro Anticancer Activity and In Silico Target Profiling of 5-(Piperazin-1-ylsulfonyl)-1,3-oxazole-4-carbonitriles.

Oleksandr O Severin, Denys Bondar, Olga Bragina, Nandish M Nagappa, Janari Olev, Volodymyr S Brovarets, Ivan V Semenyuta, Yevgen Karpichev

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oleksandr O SeverinDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 15 Akadeemia Rd., 12618 Tallinn, Estonia.ORCID 0000-0003-3943-5063
Denys BondarDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 15 Akadeemia Rd., 12618 Tallinn, Estonia.ORCID 0000-0003-3456-6742
Olga BraginaDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 15 Akadeemia Rd., 12618 Tallinn, Estonia.ORCID 0000-0001-5281-7758
Nandish M NagappaDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 15 Akadeemia Rd., 12618 Tallinn, Estonia.ORCID 0000-0002-0116-1661
Janari OlevDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 15 Akadeemia Rd., 12618 Tallinn, Estonia.ORCID 0009-0009-2781-1296
Volodymyr S BrovaretsDepartment of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Academician Kukhar Str., 1, 02094 Kyiv, Ukraine.ORCID 0000-0001-6668-3412
Ivan V SemenyutaDepartment of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases, V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Academician Kukhar Str., 1, 02094 Kyiv, Ukraine.ORCID 0000-0001-8464-3692
Yevgen KarpichevDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 15 Akadeemia Rd., 12618 Tallinn, Estonia.ORCID 0000-0003-2322-6750

Funding

Estonian Research Council COVSG5Horizon Europe Marie Skłodowska-Curie Action
6 · The paper itself

Abstract

Sulfonylated 5-piperazine-substituted 1,3-oxazole-4-carbonitriles were synthesized and evaluated for in vitro anticancer activity. Cytotoxicity was assessed in hepatocellular (HepG2, Huh7), breast (MCF-7, MDA-MB-231), cervical (HeLa), melanoma (M21), and neuroblastoma (Kelly, SH-SY5Y) cell lines, with HEK293 cells used as a non-malignant control. Compounds

Indexed as

Antineoplastic AgentsOxazolesCell Line, TumorCell ProliferationComputer SimulationDoxorubicinHEK293 CellsHumansMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsDoxorubicinOxazolesanticancer drugscancerdoxorubicinkinaseoxazole

Identifiers

PMID41752072
PMCPMC12940612

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.